Ertugliflozin in Acute Heart Failure

• Status: Recruiting
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effects on heart failure signs and symptoms of the use of either ertugliflozin, metolazone or placebo, in conjunction with intravenous loop diuretic use in acute settings and chronic oral loop diuretic therapy.

There are two general purposes for this study. The proposed study is both larger and more rigorous than essentially all PK/PD studies that form the basis of current practice with loop diuretics as well as all studies looking at add-on thiazide therapy (current guideline-recommended adjuvant). The second is to generate a mechanistic understanding of the pleotropic cardio-renal factors with chronic therapy that differentiate ertugliflozin from traditional diuretics particularly in how they maintain reduced blood volume without the complication of over-diuresis and volume depletion.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yale University
• Collaborator: Merck Sharp & Dohme Corp.
• Treatments: 5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-hydroxymethyl-6,8-dioxabicyclo(3.2.1)octane-2,3,4-triol; Ertugliflozin; Metolazone

Criteria

Inclusion Criteria:

1. A clinical diagnosis of ADHF with at least one objective sign of volume overload (rales, edema, elevated JVP, or preadmission weight gain)

2. As judged by the treating physician, a projected need and ability to tolerate treatment with an extended need for IV diuretics with the goal of significant fluid removal (i.e., goal >1L/day net fluid loss)

3. Chronic daily oral loop diuretic dose > or equal to 20mg furosemide equivalents for at least one month prior to admission

4. eGFR 30 mL/min/1.73 m2

5. Signed informed consent

Exclusion Criteria:

1. Current use or plan to initiate renal replacement therapy or ultrafiltration this hospital admission

2. Significant bladder dysfunction or urinary incontinence

3. Inability to comply with the serial urine collection procedures

4. Current use of a thiazide or thiazide like diuretics or use within 5 half-lives of the drug, including metolazone

5. Prior heart transplant, critical stenotic valvular disease or complex congenital heart

6. History of type 1 diabetes, diabetic ketoacidosis, "brittle" diabetes or frequent hypoglycemia or severe hypoglycemic episodes requiring emergent intervention (ER visit or EMS response, glucagon administration or forced oral carbs) in the last 3 months

7. History of or current urosepsis or frequent urinary tract infections

8. Anemia with hemoglobin <8g/dL (due to required phlebotomy for the study)

9. Pregnancy or breastfeeding