Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes
Status:
Withdrawn
Trial end date:
2012-10-01
Target enrollment:
Participant gender:
Summary
Preterm Premature Rupture of Membranes (PPROM) is treated with an antibiotic, erythromycin or
azithromycin, to prolong pregnancy. Erythromycin is taken for several days and can result in
stomach upset in some patients, causing them to stop taking the medication. Therefore,
azithromycin is often prescribed instead. Azithromycin is usually taken only once and stomach
upset is not seen or greatly reduced. The goal of this study is to see if there is a
difference between the antibiotic (azithromycin) compared to the antibiotic (erythromycin) in
prolonging pregnancy in patients with Preterm Premature Rupture of Membranes (PPROM). The
working hypothesis is that there is no difference in the clinical effectiveness between
antibiotic regimens containing the macrolides azithromycin and erythromycin for prolonging
latency in PPROM.