Escitalopram in Depressive Patients With Acute Coronary Artery Syndrome

• Status: Completed
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aimed to evaluate the efficacy and safety of escitalopram in the treatment of depressive patients with acute coronary artery syndrome (CAS).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chonnam National University Hospital
• Collaborator: H. Lundbeck A/S
• Treatments: Citalopram; Dexetimide

Criteria

Inclusion Criteria:

• Aged 18~85

• Diagnosed as acute CAS (unstable angina or acute myocardial infarction) and being conducted coronary angiography

• Beck Depression Inventory > 10 and major or minor depressive disorder by the DSM-IV criteria

• With ability to complete various questionnaires

• Can understand the objective of the study and sign informed consent

Exclusion Criteria:

• Occurrence of acute CAS while the patient was hospitalized for another reason, except for CAS

• Current CAS developed less than 3 months after coronary artery bypass graft procedure

• Uncontrolled hypertension (systolic BP > 180mmHg or diastolic BP > 100mmHg)

• Resting heart rate < 40/min

• Severe physical illnesses threatening life or interfering with the recovery from CAS

• Persistent clinically significant laboratory abnormalities

• Concomitant use of class I antiarrhythmic medications; reserpine, guanethidine, clonidine, or methyldopa; anticonvulsants or neuroleptics

• History of neuropsychiatric illnesses such as dementia, Parkinson's disease, brain tumor, psychoses, alcoholism, and other substance dependence

• Pregnancy