Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients

• Status: Recruiting
• Trial end date: 2024-06-10
• Target enrollment: 0
• Participant gender: All

Summary

To explore the effects of esketamine combined with remimazolam on postoperative sleep disturbance and anxiety in surgical patients undergoing gastroenteroscopies

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tianjin Medical University General Hospital
• Treatments: Esketamine; Propofol

Criteria

Inclusion Criteria:

1. Age 20-65 years old;

2. ASA classification is grade I-III;

3. Elective surgery is proposed

4. BMI of 19-30 kg/m2;

5. Patients who agreed to enroll in this study voluntarily

Exclusion Criteria:

1. Those who are known to be allergic to the drug ingredients in this study and their allergic constitution;

2. Allergic history of general anesthesia drugs, opioid drugs, non-steroidal drugs;

3. History of neurological diseases; History of chronic pain; Drug and alcohol addiction; A long history of opioid use; Opiates were given 48 hours before surgery;

4. ASA rating of IV or V;

5. Coronary heart disease, bronchial asthma, severe hypertension, severe blood system dysfunction, liver and kidney function, electrolyte abnormalities;

6. History of gastrointestinal disease (peptic ulcer, Crohn's disease, ulcerative colitis);

7. Respiratory insufficiency, respiratory failure;

8. Patients who refused to use intravenous PCA for analgesia;

9. Pregnant or lactating women;

10. BMI<18 kg/m2 or BMI>30kg/m2;

11. Poor compliance, unable to complete the experiment according to the study plan;

12. Participants who have participated in clinical trials of other drugs within the last 4 weeks;

13. Any circumstances deemed unsuitable for inclusion by the researcher for any reason.