Esketamine-propofol Versus Propofol for Flexible Bronchoscopy

• Status: Not yet recruiting
• Trial end date: 2023-09-30
• Target enrollment: 0
• Participant gender: All

Summary

Bronchoscopy is a promising technology for lung and bronchus disease detection and therapy. However, this procedure is associated with a relatively high risk of hypoxemia, coughing, wheezing, and dyspnea. Despite the fact that propofol is the most commonly used agent in procedure sedation, the narrow therapeutic index remains challenging. Esketamine is the s-enantiomer of ketamine with potent analgesic and sedative properties. This study aims to test the hypothesis that adding subanesthetic esketamine to propofol is non-inferior to propofol alone for bronchoscopy on the recovery profile and discharge from the hospital.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fujian Provincial Hospital
• Treatments: Esketamine; Ketamine; Propofol

Criteria

Inclusion Criteria:

1. American Society of Anesthesiologists (ASA) classification I-III;

2. Scheduled for ambulatory bronchoscopy.

Exclusion Criteria:

1. Allergic or contraindications to studying drugs

2. History of obstructive sleep apnea-hypopnea syndrome

3. History of psychiatric illness

4. History of neurological disease

5. Pre-existing memory or cognitive impairment

6. History of seizure disorders

7. Pregnancy

8. Substance abuse or intake of drugs that affect the central nervous system

9. Inability to communicate in Mandarin Chinese.

10. Illiteracy