Esmolol Effects on Heart and Inflammation in Septic Shock
Status:
Unknown status
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
Beta adrenergic system, over-activated in septic shock patients, is a key modulator of the
inflammatory response. Experimental works demonstrated that Esmolol, an highly selective
beta-1 blocker, reduces heart rate and regulates the inflammatory response. A recent mono
centric, double blind, randomized clinical work in septic shock patients has shown that
Esmolol administration is safe and reduces effectively heart rate. However there are only
sparse data on 1) regional and micro-circulation, 2) inflammation modulation in human
resuscitated septic shock patients treated by esmolol.