Esmolol Infusion During Laminectomy: Effect on Quality of Recovery

• Status: Terminated
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and requirements for pain medication.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cedars-Sinai Medical Center
• Treatments: Esmolol

Criteria

Inclusion Criteria:

• Patients scheduled to undergo single-level or double-level laminectomy under general anesthesia

• Willingness and ability to sign an informed consent document

• No allergies to any of the anesthetic or analgesic medications being used for the study, as outlined in the study protocol

• Between 18-80 years of age

• American Society of Anesthesiologists (ASA) class I-III adults of either sex

Exclusion Criteria:

• Patients who are ASA class IV or higher

• Patients with known allergy, hypersensitivity, or contraindication to the use of any of the medications being used for the study, as outlined in the study protocol

• Patients who are heavy chronic opioid users, defined for the purposes of this study as any patient who is taking the equivalent of 10mg of oral morphine per day or greater

• Pregnant or lactating women

• Patients with a history of drug or alcohol abuse within the past 3 months

• Patients with any other medical conditions or who are using any medications which may interfere with the conduct of the study (including patients taking clonidine, patients with EKG conduction defects and who are taking calcium channel blockers, patients with clinically significant congestive heart failure (CHF) or bronchospasm, or patients with second- or third-degree heart block, symptomatic sinus bradyarrhythmia, or nonsinus rhythm on preoperative EKG.)