Esmolol Infusion in Patients Undergoing Craniotomy

• Status: Completed
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Anesthesia techniques that minimize anesthetic requirements and their effects may be beneficial. Esmolol, a short acting hyperselective β-adrenergic blocker is effective in blunting adrenergic response to several perioperative stimuli and so it might interfere in the effect of the anesthetic drugs on the brain. This study was designed to investigate the effect of esmolol on the consumption of propofol and sevoflurane in patients undergoing craniotomy.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: George Papanicolaou Hospital
• Treatments: Anesthetics; Esmolol; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Patients with ASA physical status 1-3

• Glasgow Coma Scale:15

Exclusion Criteria:

• Patients with ASA physical status >3,

• Body Mass Index (BMI) over 30,

• indication for rapid sequence induction,

• any contraindication for receiving b-blocker,

• chronic use of b-blocker,

• Glasgow Coma Scale (GCS) <15,

• history of drug abuse,

• severe mental impairment,

• preoperative aphasia,

• neurologic deficit or preoperatively foreseen delayed extubation.