Esmolol Versus Dexmedetomidine During Intracranial Procedures

• Status: Unknown status
• Trial end date: 2017-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients undergoing intracranial procedures may experience severe hypertension and tachycardia due to intracranial hypertension and to increased release of adrenaline. Preventing perioperative sympathetic activity is of great importance. A common technique is using b-blockers like esmolol, which effectively block perioperative hemodynamic changes during intracranial surgery. A2 agonists, like Dexmedetomidine-Dex are now being used as a component of a balanced anesthesia during neurosurgical procedures. This study aimed to evaluate whether esmolol or dex attenuates perioperative changes in patients undergoing elective craniotomy with fast track neuroanesthesia.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: George Papanicolaou Hospital
• Treatments: Adrenergic Agents; Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic Antagonists; Dexmedetomidine; Esmolol

Criteria

Inclusion Criteria:

• Patients with ASA physical status 1-3

• Glasgow Coma Scale:13-15

• Hunt-Hess: 0-3

Exclusion Criteria:

• Patients with ASA physical status >3,

• Body Mass Index (BMI) over 30,

• indication for rapid sequence induction,

• any contraindication for receiving b-blocker,

• Glasgow Coma Scale (GCS) <13,

• history of drug abuse,

• neurologic deficit or preoperatively foreseen delayed extubation,

• preoperative heart rate<45.