Esophageal Hypersensitivity Study in Patients With Gastroesophageal Reflux Disease (GERD)

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to compare sensitivity of visceral pain in the esophagus using different pain stimuli.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: AstraZeneca

Criteria

Inclusion Criteria:

• Provision of signed informed consent form

• BMI 18.5-35.0, inclusive

• Continuous PPI treatment for GERD during the last 4 weeks

Exclusion Criteria:

• Patients that have not experienced any GERD symptoms improvement at all after PPI treatment

• Unstable or clinically significant disorders including cardiovascular, respiratory, renal, hepatic, metabolic, psychiatric, other gastrointestinal and esophageal disorders besides GERD

• Prior surgery of the upper GI tract