Estimate the Efficacy of HD6610 Granule for Oxaliplatin-induced Peripheral Neuropathy

• Status: Unknown status
• Trial end date: 2017-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to estimate the usefulness and safety of HD6610 granule for oxaliplatin-induced peripheral neuropathy. The investigators examined the efficacy and safety of the treatment algorithm for 64 patients with colorectal cancer by evaluating the side effects and degree of improvement of subjective symptoms.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jiangsu Province Hospital of Traditional Chinese Medicine
• Treatments: Fluorouracil; Leucovorin; Oxaliplatin

Criteria

Inclusion Criteria:

1. All cases have been diagnosed with colorectal cancer by pathology;

2. Patients who received no chemotherapy before should receive oxaliplatin-based chemotherapy(FOLFOX4,FOLFOX6,XELOX) ;

3. Patients of 18-70 years old have no serious heart,liver,kidney and hematopoietic disfunction,life expectancy of over 3 months and KPS more than 60;

4. Patients with no positive sign in neurological examination,and no drug allergy history or diabetes;

5. Volunteered to participate and signed informed consent,patients can not receive radiotherapy,acupuncture and moxibustion or other treatment during the experiment.

Exclusion Criteria:

1. Not accordant with the inclusion criteria;

2. Patients who have used herbal within 4 weeks before registration;

3. Patients who have serious heart,liver,kidney and hematopoietic disfunction;

4. Patients of central nervous system disease;

5. Patients of cervical spondylopathy,lumbar disc protrusion,diabetes and uremia which can potentially cause peripheral neuropathy;

6. Nerve compression caused by tumor metastasis or peripheral neuropathy caused by electrolyte disturbances,diabetes,alcohol disease and other disorder;

7. Long-time using of thiazide diuretic and foxglove;

8. Patients of poisoning,infection and radiotherapy which induced peripheral neuropathy or receiving medicine which can cause peripheral neuropathy;

9. Patients who can hardly take Chinese Medicine with severe diarrhea,vomiting or intestinal obstruction ;

10. Uncontrolled psychosis;

11. Women of pregnancy ,preparing pregnant, or lactation;

12. Alcohol and drug abuse;

13. Allergic constitution or allergy to experiment drugs.