Estimation of Paracetamol in Urine to Assess the Diurnal Variation

• Status: Completed
• Trial end date: 2018-01-30
• Target enrollment: 0
• Participant gender: Male

Summary

Paracetamol is an antipyretic drug that is taken orally at different times of the day in same dose. It is excreted mainly through renal route which may show diurnal variation. In this study, urinary excretion of paracetamol of 41 healthy men of same age group will be measured by HPLC after oral administration of 500 mg paracetamol tablet at morning, midday and night. The measured values will be compared in order to adjust doses of oral paracetamol at different times of the day.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• The healthy male student volunteers of Eastern Medical College having age range between 19 and 23 years

Exclusion Criteria:

• Age <19 years , >23 years

• Volunteers on analgesic or antipyretic medication

• Volunteers with history of hypersensitivity to paracetamol

• Volunteers taking any enzyme inducing or enzyme inhibiting drug

• Volunteers with impaired renal or hepatic function