Estradiol Effects on Alcohol Across the Menstrual Cycle
Status:
Recruiting
Trial end date:
2025-09-30
Target enrollment:
Participant gender:
Summary
This study will provide the first rigorous integrative test of the hypothesis that rapid
rises in estradiol (a female hormone) increase the rewarding and disinhibiting effects of
alcohol and that such increased sensitivity correlates with increased alcohol use.
Identification of the behavioral mechanisms by which estradiol surges can increase alcohol
use would provide a critical advancement of neurobiological theory of alcohol abuse in women,
an understudied area, as well as provide new directions for personalization of alcohol abuse
treatment in women.
In this study, naturally-cycling women will be examined daily over their menstrual cycle
using an integrative combination of daily ecological assessments of hormone fluctuations and
alcohol use along with strategically-timed laboratory tests of their acute sensitivity to the
rewarding and disinhibiting effects of a controlled dose of alcohol.
Phase:
N/A
Details
Lead Sponsor:
Mark Fillmore
Collaborator:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)