Estradiol Pretreatment With Misoprostol in Second Trimester Miscarriage

• Status: Completed
• Trial end date: 2018-12-20
• Target enrollment: 0
• Participant gender: Female

Summary

To compare the effectiveness of estradiol pretreatment with misoprostol and vaginal misoprostol alone in induction of second trimestr miscarriage.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Misoprostol; Polyestradiol phosphate

Criteria

Inclusion Criteria:

• Maternal age more than 18 years old (age of legal consent).

• Gestational age between 12-26 weeks.

• Hb level > 10 g/dL.

• BMI between 25 kg/m2 and 35 kg/m2.

• Missed abortion.

• Living fetus with multiple congenital malformations incompatible with life.

• PPROMS with drained liquor and parents are consenting for termination of pregnancy.

Exclusion Criteria:

• Maternal age less than 18 years old.

• Gestational age less than 12 weeks or more than 26 weeks.

• Hb level < 10 g/dL.

• Scared uterus (previous myomectomy - cesarean section - hysterectomy and ruptured uterus).

• Polyhydramnios.

• Anencephaly.

• Fibroid uterus.

• BMI less than 25 kg/m2 and more than 35 kg/m2.

• Coagulopathy.

• Previous attempts for induction of abortion in the current pregnancy.

• Allergy to misoprostol or estradiol.

• Placenta previa.

• Medical disorder that contraindicate induction of abortion (e.g. heart failure).