Estrogen (Gel)Transdermal vs Oral Estrogen for Endometrial Preparation
Status:
Not yet recruiting
Trial end date:
2024-09-01
Target enrollment:
Participant gender:
Summary
The goal of this randomized study trial is to comparing transdermal estradiol gel and oral
estradiol for endometrial preparation in the Frozen Embryo Transfer Cycle. The main
question[s] it aims to answer is: • Can Transdermal estrogen (gel) can be equally efficacious
as compared to oral estrogen in hormone replacement FET (HRT- FET) cycles ? The Transdermal
gel would have the added benefit of a higher patient comfort with fewer side effects and a
better safety profile. Participants planned for Frozen embryo transfer will undergo H-P-O
axis suppression on previous cycle D21 of menses with gonadotropin-releasing hormone(GnRH)
agonist depot preparation (Inj. Decapeptyl 3.75 mg) IM . The study will compare Transdermal
E2 gel with Oral E2 tabs. The patients will be randomized into an oral and gel group, and all
patients will participate only once in the study.