Estrogen, Probiotics and Vaginal Health to Prevent HIV Infection in ACB Women
Status:
Recruiting
Trial end date:
2022-03-31
Target enrollment:
Participant gender:
Summary
This study will enrol African, Caribbean and Black (ACB) women who are known to have a more
diverse vaginal microbiome, higher rates of bacterial vaginosis with lower numbers of
protective lactobacilli, and are at increased risk for HIV. The investigators will evaluate
the safety, feasibility, effect on the vaginal bacterial microbiome and changes in local
immune and inflammatory responses with the administration of vaginal estrogen alone, vaginal
estrogen in combination with oral or vaginally administered probiotics, or vaginal probiotics
alone.