Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery

• Status: Terminated
• Trial end date: 2005-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to test whether perioperative estrogen replacement in postmenopausal women reduces the risk for neurologic injury after coronary artery bypass graft (CABG) surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Estrogens

Criteria

Inclusion Criteria:

• Patients whose scheduled procedure is CABG surgery OR

• Patients whose scheduled procedure is isolated aortic surgery OR

• Patients whose scheduled procedure is mitral valve surgery OR

• Patients whose scheduled procedure is CABG combined with aortic or mitral valve surgery

Exclusion Criteria:

• Patients having re-operations

• Patients having combined carotid endarterectomy with CABG surgery

• Patients having CABG with tricuspid valve surgery

• Patients having mitral and aortic valvular surgery (with or without CABG surgery)

• Elevation of liver function test before surgery or creatinine before surgery greater than 2 mg/dl

• Emergency surgery

• Severe cognitive impairment before surgery as indicated by clinical history and/or a score greater than 12 on the Short Blessed Dementia Screening Test (see d11)

• Inability to attend outpatient visits

• A history of venous thromboembolism

• Unexplained vaginal bleeding

• A history of breast cancer or personal history of endometrial cancer in the absence of hysterectomy

• Estrogen use within 6 months of the surgery

• Patient refusal to participate

• Inability to speak and read English or visual impairment