Estrogen in the Prevention of Adhesion Reformation
Status:
Enrolling by invitation
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Asherman syndrome, which occurs after trauma to the basalis layer of the endometrium.It seems
that the role of postoperative estrogen therapy in the prevention of recurrence of IU
adhesions is still controversial. To investigate if estrogen therapy can prevent adhesion
reformation after adhesiolysis.
After the completion of hysteroscopic adhesiolysis, recruited patients will be randomized to
one of the two treatment groups by computer-generated numbers: having estrogen after
hysteroscopic adhesiolysis three months, all patients in this group will be treated with
hormone therapy for 3 cycles; each cycle consists of estradiol 4mg per day for 21 days with
addition of progestogen in the form of dydrogesterone 10mg per day for the last 7 days; and
the control group without estrogen treatment. A second-look hysteroscopy and ultrasound
assessment of the endometrium will be carried out 4 weeks after the surgery, and again at 8
weeks after the surgery.