Estrogens Effect on Pain in Postmenopausal Women Suffering of Fibromyalgia

• Status: Terminated
• Trial end date: 2007-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

In order to evaluate the potential effects of estrogen treatment in postmenopausal women with fibromyalgia, the investigators used quantitative sensory tests before and after eight weeks of estrogen treatment as compared with placebo treatment.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ostergotland County Council, Sweden
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Estrogens; Polyestradiol phosphate

Criteria

Inclusion Criteria:

• Between 49-60 years

• Body mass index (BMI) of < 30

• Met the ACR-90 criteria for the diagnosis of fibromyalgia

• Postmenopausal state since at least six months

• Not been using any hormonal treatments for the past three months

• Had normal mammography screenings

Exclusion Criteria:

• Using psychotropic drugs or having a history of thromboembolism

• Diabetes mellitus, polyneuropathy, chronic liver disease,

• Alcohol or substance abuse, hemoglobinopathy,

• Endometrial adenomatous hyperplasia, or malignancy.

• Presence of untreated hypertension (>160/95).

• Undiagnosed vaginal bleedings