Ethnic Differences in Mechanisms of Action of Dupilumab
Status:
Not yet recruiting
Trial end date:
2024-04-01
Target enrollment:
Participant gender:
Summary
Previous research has shown that Asian and African Americans are more likely to develop
atopic dermatitis (AD) than their Caucasian counterparts. However, limited information is
known about AD in Asian and African American populations because most molecular studies have
focused on Caucasians with AD.
This trial will determine differences in inflammatory responses to dupilumab between
Caucasian, Asian, and African American patients with AD.
The central hypothesis of this study is that ethnic differences in both immune and stromal
cells contribute to variability in AD presentation and response to anti-interleukin-4
receptor (IL-4R) inhibition with dupilumab.