Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial
Status:
Completed
Trial end date:
2013-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is:
1. -to determine whether benznidazole (BZN) will be able to modify the natural evolution of
chronic Chagas disease in adult patients by means of a randomized, double-blind clinical
trial (RCT).
Also:
2. -to validate therapeutic efficacy with new methods, such as recombinant antigen F29 of
Trypanosoma cruzi visualized by conventional ELISA, in the context of the RCT compared
with conventional serology (CS)
3. -to develop the real-time polymerase chain-reaction (RT-PCR) to quantify the parasite
load as an early therapeutic effect.
4. to determine the potential of such serological and parasitological methods as predictors
of therapeutic effect or failure.
Phase:
Phase 3
Details
Lead Sponsor:
Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben
Collaborators:
Becas Carrillo Oñativia, Ministerio de Salud, Argentina Drugs for Neglected Diseases National Council of Scientific and Technical Research, Argentina Pan American Health Organization