Etiology, Assessment and Treatment of Post-gastric Bypass Severe Hypoglycemia

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: All

Summary

With increasing rates of obesity the number of anti-obesity operations performed is increasing; one of the most common is gastric bypass. Anti-obesity surgery ameliorates diabetes and several other serious comorbidities, but bariatric surgery is also associated with medical and nutritional complications.

Post-gastric bypass hyperinsulinemic hypoglycemia is a relative rare but serious complication often seen months to years after gastric bypass surgery. The patients experience neuroglycopenic symptoms (eg. inability to concentrate, weakness, altered mental status, loss of consciousness).

The purpose of this study is to determine whether glucagon-like peptide-1 (GLP-1)or other enteropancreatic factors (eg. gastric emptying rate) are responsible for the excessed insulin secretion seen in some patients after bariatric surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Collaborator: Region MidtJylland Denmark
• Treatments: Glucagon; Glucagon-Like Peptide 1; Octreotide; Somatostatin

Criteria

Inclusion Criteria:

• Male/female

• Legally competent (habil)

• Age 20-65 years

• Speak and understand Danish

• Written consent

• Investigators verification of suitability

Exclusion Criteria:

• Heart, liver or kidney disease

• Treatment with Cortisol

• Current treatment with antidiabetic medication

• Epilepsy

• Abuse/addiction to drugs