Evaluate a Medication on How Hunger and Appetite Are Influenced by Smell

• Status: Terminated
• Trial end date: 2009-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the blood pressure medication, diltiazem, will temporarily decrease the sense of smell when given in a nasal spray which will then reduce food intake.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pennington Biomedical Research Center
• Collaborator: Compellis Pharmaceuticals
• Treatments: Diltiazem

Criteria

Inclusion Criteria:

• Body mass index (BMI) between 25 and 40 kg

• Blood pressure in within normal range

Exclusion Criteria:

• Used tobacco products in the past month

• Used a calcium channel blocker medication in the last month

• used nasal sprays in the last month

• have an abnormal sense of smell or abnormalities of the lining in your nose

• female and have irregular menstrual periods

• female and are nursing a baby or pregnant

• female and have had a partial hysterectomy (still have ovaries)