Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload
Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
This is a clinical research study in patients who have iron overload in the heart due to
chronic blood transfusions.
The study will have 2 treatment groups and will compare the safety and efficacy of chelation
therapy with a medicine called deferasirox (ICL670) with another medicine called deferoxamine
(DFO). The study is aimed at finding out which of the two medicines is the best for treating
iron overload in the heart.
Patients will be treated for 12 months (core study phase). Patients who complete the core
study phase will be offered to continue their study treatment in a 12 months extension phase.
During the core and extension, the effects of treatment on iron overload in the heart and the
liver will be evaluated using specific magnetic resonance imaging (MRI) assessments.