Evaluating Vitamin D3 Supplement on Post-Op Outcomes

• Status: Active, not recruiting
• Trial end date: 2022-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to determine if vitamin D supplementation is associated with differences in short-term recovery in patients following total knee arthroplasty compared to patients who do not receive supplementation. If so, vitamin D supplementation has the potential to become widely incorporated into the routine care for patients undergoing knee replacements.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rush University Medical Center
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Any patient undergoing primary total knee arthroplasty for osteoarthritis

• Age ≥ 18 years old

• Willingness to undergo randomization and return for all scheduled visits

Exclusion Criteria:

• Age > 80 years old

• American Society of Anesthesiologists (ASA) Score ≥ 4

• Other supplemental vitamin D or Calcium use including their analogs: ergocalciferol, calcitriol, dihydrotachysterol, and paricalcitol

• Current cancer

• Malabsorption syndromes

• Inability to take medications orally

• Renal impairment defined as a glomerular filtration rate (GFR) < 30 mL/minute or creatinine >1.3 mg/dL

• History of hypercalcemia defined as albumin-corrected hypercalcemia >12 mg/dL