Evaluating the Influence of the Strategy Intraoperative Anesthetic (Desflurane Versus Propofol) on Cognitive and Psychomotor Functions in Output Post Interventional Room Monitoring - COGNIDES

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The recovery of cognitive and psychomotor functions is best performed under anesthesia after desflurane when propofol in that obtaining a Aldrete score> 8/10 output of the allowing SSPI.

The principal objective is to compare the cognitive and psychomotor status of patients recovered an Aldrete score> 8/10 according to the anesthetic agent (propofol or desflurane) using three tests (Stroop test, Digit Symbol Substitution task and a test of verbal memory (visual verbal learning test) made SSPI.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Anesthetics; Desflurane; Isoflurane; Propofol

Criteria

Inclusion Criteria:

• Age ≥ 18 years and ≤ 80 years

• ASA I, II

• General anesthesia provided

• Scheduled orthopedic surgery

• Duration of surgery between one and three hours

• Patient has given its written consent

• Patient receiving medical health insurance

Exclusion Criteria:

• MMS (Mini Mental State) ≤ 24

• Patient does not speak or read or do not understand the French

• Previous surgery within seven days

• Coronary insufficiency, renal, hepatic

• Chronic pulmonary disease

• Obesity (BMI> 35)

• Addiction

• Chronic alcoholism

• Hematocrit <25%

• Personal and family history of malignant hyperthermia

• Taking benzodiazepines or psychotropic within 24 hours preoperative

• Psychiatric pathology being

• Psychological or neurological disorder causing difficulties in understanding the study

• Chronic pain and / or taking analgesics 3.

• Pregnancy or breastfeeding

• Disorder of hemostasis: platelets <80,000 / mm3, PT <50% TCA> 1.5 times the control.

• Hypersensitivity to propofol or desflurane or any of the excipients

• Patients allergic to soy and peanuts

• History of liver disease, jaundice, unexplained fever, eosinophilia after administration of a halogenated anesthetic

• Hypersensitivity to egg lecithin.