Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Female Subjects.

• Status: Completed
• Trial end date: 2015-11-13
• Target enrollment: 0
• Participant gender: Female

Summary

This study was a single-center positive-controlled, randomized, dose-escalation study of HSK3486 in healthy female subjects administered as a single IV bolus dose.Subjects were confined to the study unit from the evening of Day -1 until the morning of Day 2, then were required to return for a follow up visit on Day 5. Intensive safety, PD and PK assessments were performed prior to dosing on Day 1 until 24 hours post-dose (Day 2).

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sichuan Haisco Pharmaceutical Group Co., Ltd; Sichuan Haisco Pharmaceutical Group Co., Ltd.
• Treatments: Propofol

Criteria

Inclusion Criteria:

• Female, aged 18 - 49 years (inclusive)

• Women of child-bearing potential agreed to use adequate contraception prior to study entry, for the duration of study participation, and for 90 days following completion of therapy

• Negative serum pregnancy test

• In general good health without CS medical history

• American Society of Anesthesiologists (ASA) Physical Status Classification of I or II

• Body Mass Index (BMI) between 18 and 30 kg/m2 (inclusive)

• Negative screen for drugs of abuse, alcohol, hepatitis B surface antigen (HBs-Ag), hepatitis C virus antibody (HCV-Ab) and Human Immunodeficiency Virus (HIV) at screening; and drugs of abuse, alcohol pre dose on Day -1

• Normal or non-CS findings on a physical examination, 12-lead Electrocardiogram (ECG) and vital signs (respiratory rate between 12 and 20 breaths per minute, blood pressure (BP) between 100-140/60-90 mmHg, heart rate between 50-99 beats per minute, temperature between 35.8°C and 37.5°C and pulse oximetry values > 95% on room air)

• Clinical laboratory values within the normal limits as defined by the clinical laboratory, unless the PI decided that out-of-range values were not CS

• Able to provide written informed consent

• Willing and able to follow study instructions and likely to complete all study requirements

• Suitable venous and arterial access

Exclusion Criteria:

• History of allergy or sensitivity to: propofol, components of Fresofol 1% MCT/LCT propofol, or HSK3486 (excipients soy bean oil, glycerine, triglycerides, purified egg phospholipids, sodium oleate and sodium hydroxide), or plain lignocaine

• History of CS problems with general anesthesia

• Current smoker, or a history of regular (more than weekly) use of tobacco- or nicotine-containing products within 2 months prior to screening

• History of excessive alcohol intake (more than four standard drinks daily, on average) or use of recreational drugs within the last 3 months CONFIDENTIAL HSK3486 SAD_02 Sichuan Haisco Pharmaceutical Co., Ltd Version: 13 Nov 2015 Page 19 of 513

• Use of prescription or over the counter medications within 7 days of Investigational Product administration, with the exception of contraceptive medications, paracetamol, oral non-steroidal anti-inflammatory agents, topical over the counter preparations and routine vitamins (if they do not exceed an intake of 20 to 600 times the recommended daily dose), unless agreed as non-clinically relevant by the PI and Sponsor.

• Standard donation of blood within 30 days of the study

• Donation of plasma or participation in a plasmapheresis program within 7 days preceding this study

• Receipt of any investigational study drug within 30 days prior to screening

• Unable to fast for the 6 hours prior to Investigational Product administration

• CS (as judged by the Investigator) presence of acute illness (e.g. gastrointestinal illness, infection such as influenza, upper respiratory tract infection) at admission to the clinical study unit

• Anticipated need for surgery or hospitalization during the study

• Anatomical abnormality that would potentially interfere with airway management under unconscious sedation or anesthesia

• History of posture-related gastric reflux more than twice weekly

• History of seizures or epilepsy

• History of ischaemic heart disease

• History of brady- or tachy-dysrhythmias requiring medical care

• History of asthma, with bronchospasm requiring treatment in the last 3 months

• Any condition, which in the Investigator's opinion, puts the subject at significant risk, could confound the study results or may interfere significantly with the subject's participation in the study.