Evaluating the Use of Prednisone to Decrease Pegylated Interferon Beta-1a Side Effects

• Status: Unknown status
• Trial end date: 2020-05-31
• Target enrollment: 0
• Participant gender: All

Summary

Some of the most common side effects of the multiple sclerosis drug Plegridy (pegylated interferon beta-1a) include flu-like symptoms and injection site reactions. Physicians often advise patients to take Tylenol or aspirin prior to injection, but in this study the investigators evaluated whether using a low dose of oral steroid in combination with Tylenol reduced flu-like symptoms and injection site reactions.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Holy Name Medical Center, Inc.
• Collaborator: Biogen
• Treatments: Acetaminophen; Interferon beta-1a; Interferon-beta; Interferons; Prednisone

Criteria

Inclusion Criteria:

• diagnosed any form of MS (relapsing remitting, primary progressive, secondary progressive), any EDSS (expanded stability status scale) score

Exclusion Criteria:

• prior allergic reaction to interferon products, congestive heart failure, elevated liver enzymes