Evaluation of Accelerometer-Based Neuromuscular Monitoring Reliability to Exclude Postoperative Residual Paralysis
Status:
Completed
Trial end date:
2012-07-01
Target enrollment:
Participant gender:
Summary
Accelerometer-based neuromuscular monitoring is not the gold-standard method to evaluate
residual postoperative paralysis but it represents the most simple, inexpensive and
widespread tool in clinical practice. Train-of-four ratio (TOF-ratio) of 100% is considered
the gold-standard to avoid PORC (post operative residual curarization).
This clinical trial is conducted to verify the reliability of accelerometer-based
neuromuscular monitoring in order to exclude postoperative residual paralysis which is not
highlighted by this instrument at a TOF-ratio=100%.
The study evaluates patients' neuromuscular recovery evaluated using pulmonary function tests
after extubation at a TOFratio=100%. Administering placebo or sugammadex at a TOF ratio=100%
allows to evaluate whether the recovery of muscle function is concrete, although the
monitoring device shows a complete decurarization; patients treated with sugammadex should
not be capable to perform better pulmonary function tests if a TOF ratio=100% is reliable.
Phase:
N/A
Details
Lead Sponsor:
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano