Evaluation of Adrenal Androgens in Normal and Obese Girls After Suppression and Stimulation
Status:
Recruiting
Trial end date:
2022-03-01
Target enrollment:
Participant gender:
Summary
Women with polycystic ovary syndrome (PCOS) often have irregular menstrual periods, too much
facial and body hair, and weight gain. Women with PCOS also have a hard time becoming
pregnant. Girls with high levels of the male hormone testosterone often develop PCOS as
adults. Some girls with high levels of male hormone will develop normal hormone levels as
they grow up, but most girls continue to have high levels of male hormone as adults. The
purpose of this study is to understand where the male and female hormones come from in girls
as they get older. The investigators think the adrenal gland, makes most of the hormones in
young girls and that the ovary and the adrenal gland make these hormones in older girls. The
investigators would like to find out whether an overactive adrenal gland makes these hormones
higher in girls who are overweight, compared to those who are not overweight.
Phase:
N/A
Details
Lead Sponsor:
University of Virginia
Collaborators:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) University of California, San Diego