Evaluation of Aerosolized Drugs Deposition During Mechanical Ventilation

• Status: Completed
• Trial end date: 2016-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Aerosol delivery through a ventilator is influenced by numerous factors from ventilator-related, circuit-related to device-related factors. Aerosolized drug delivery through a ventilator system was studied on bench model with albuterol, yet the results were often overestimated. The objective of this study was to evaluate inhaled bronchodilator and mucolytic agents delivered through a ventilator system.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chang Gung University
• Collaborator: Chang Gung Memorial Hospital
• Treatments: Acetylcysteine; Albuterol; N-monoacetylcystine

Criteria

Inclusion Criteria:

• Mechanical ventilated patients with an endotracheal tube intubated

• Receiving aerosol therapy with salbutamol or acetylcystine

• On relatively stable medical condition

Exclusion Criteria:

• Pregnant

• Unstable hemodynamic status (e.g. blood pressure <100/60 mmHg, under Intra-aortic balloon pump)

• Infected with airborne pathogens (e.g. tuberculosis or Influenza virus)

• Poor oxygenation (fraction of inspiratory oxygen >0.8, under high frequency oscillatory ventilation, or extracorporeal membrane oxygenation)