Evaluation of Brain Damage Resulting From Carotid Endarterectomy With Xenon Anesthesia

• Status: Completed
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to show that, in patients undergoing carotid endarterectomy, brain damage, assessed by the determination of S100B before removing the clamp, is less severe with a balanced anesthesia consisting of remifentanil combined with Xenon (experimental arm) compared with remifentanil anesthesia associated with propofol (reference arm).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes
• Treatments: Anesthetics; Xenon

Criteria

Inclusion Criteria:

• The patient must have given his/her informed and signed consent

• The patient must be insured or beneficiary of a health insurance plan

• Patients with American Society of Anesthesiology (ASA) scores of 1 to 4

• Patient schelduled for carotid endarterectomy

Exclusion Criteria:

• The patient is participating in another study

• The patient is in an exclusion period determined by a previous study

• The patient is under judicial protection, under tutorship or curatorship

• The patient refuses to sign the consent

• It is impossible to correctly inform the patient

• The patient is pregnant

• The patient is breastfeeding

• The patient has a contra-indication for a treatment necessary for this study

• The endarterectomy does not require a shunt

• ASA score of 5

• Patient presenting with symptomatic gastric-oesophagien reflux

• Patient has neuro-endocrine cancer

• Patient has hypersensivity to one of the following substances: propofol, remifentanil, celocurine, cisatracurium, rocuronium, senon, paracetamol, tramadol

• Patient suffering from obstructive respiratory insufficiency (chronic obstructive pulmonary disease, asthma)

• Patient with coronary disease with severely altered cardiac function

• High intracranial pressure

• Patient requiring high concentrations of oxygen (SpO2 < 92% normal air)

• Patient with neuro-sensorial deficit that, in the absence of a prothesis, prevents reading, writing, or responding to simple orders

• Patient suffering from myopathy or recent rhabdomyolysis

• Patient with psychiatric pathology or chronic alcohol consumption or consumption of another substance that interferes with understanding

• Lack of contraception for women of child-bearing age

• History of or suspected malignant hyperthermia

• Patients with liver damage, jaundice, unexplained fever or eosinophilia after administration of a halogenated anesthetic

• Patient has undergone a recent multiple trauma (<1 month)

• Patient who received general anesthesia within the past 7 days