Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen
Status:
Recruiting
Trial end date:
2023-03-15
Target enrollment:
Participant gender:
Summary
Pain is an inseparable symptom of fractures and is the most important and common symptom that
brings patients to medical centers; Therefore, paying attention to pain and its control is
very important in the examination and treatment of fractures, and painkillers are usually
needed for effective pain control. About 70-90% of the patients who go to the emergency room
due to injuries have organ injuries. Among these patients, those who suffer from fractures
endure severe pain, and since only 10% of patients have open fractures, the pain management
of patients with closed fractures is particularly important. Various medicinal compounds have
been used so far to control the pain of fractured patients, including opioid compounds such
as morphine, non-steroidal anti-inflammatory drugs such as ibuprofen and acetaminophen.
Opioids are the main drug class for pain control in fractures, but since they have
significant side effects, various studies have been conducted in the field of comparing the
anti-inflammatory effect of different drugs in fractures, and the effect of various
combinations compared to opioids has been investigated. Non-steroidal anti-inflammatories are
always considered as an alternative to opioids and acetaminophen has also been considered to
reduce the dosage of opioids, so in this study the effect of three combinations of
intravenous morphine and ibuprofen plus intravenous acetaminophen and intravenous ibuprofen
on pain levels in patients with a closed limb fracture will be investigated.
This study is a blind randomized clinical trial, which investigates and compares the effect
of intravenous morphine (Daropakhsh Company) with intravenous ibuprofen (Caspian Taamin
Company) and intravenous acetaminophen (Caspian Taamin Company) with intravenous ibuprofen
(Caspian Taamin Company) in reducing the pain of patients with closed limb fractures. The
population investigated in this study will include all patients referred to the emergency
room of Al-Zahra and Ayatollah Kashani educational centers in Isfahan city in 2022-2023.