Evaluation of Endometriosis With 18F-fluoroestradiol PET / MRI
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
Purpose: The primary objective is to evaluate the sensitivity and specificity of
18F-fluoroestradiol (FES) PET/MRI for evaluating endometriosis.
Participants: A total of 12 participants will be recruited from individuals with clinically
suspected endometriosis who are scheduled for planned operative laparoscopy at the University
of North Carolina at Chapel Hill (UNC).
Procedures (methods): This is a prospective, one arm, single center study of 12 subjects with
clinically suspected endometriosis to demonstrate FES PET/MR's clinical utility for diagnosis
of endometriosis. This study will be an evaluation of the radiotracer, FES, which binds to
estrogen receptors and has previously been used to study estrogen receptor expression in
tumors, to detect endometriosis. Participants will undergo one FES PET/MR scan within 4 weeks
prior to their scheduled surgery. Participants will also complete questionnaires regarding
their condition, pain, and quality of life.
Phase:
Phase 2
Details
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborator:
North Carolina Translational and Clinical Sciences Institute