Evaluation of Extended Intravenous of Beta-lactams in the Treatment of Serious Gram-negative Infections in Critically Ill Patients

• Status: Unknown status
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the PK/PD parameters, safety and efficacy of extended infusion of beta-lactams in intensive care patients who are infected with Gram-negative bacteremia or pneumonia at National Taiwan University Hospital (NTUH).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: beta-Lactams; Lactams

Criteria

Inclusion Criteria:

• Adult patients (> 18 years)

• Admitted on the intensive care unit

• Starting a treatment with beta-lactams antibiotics

• Signed informed consent

• Expected to live > 3 days

Exclusion Criteria:

• renal insufficiency (estimated clearance < 20 ML /MIN)

• renal replacement therapy

• ANC < 1000 103 µl

• pregnancy

• drug abuse