Evaluation of Fluid Retention Due to Superpotent Topical Corticosteroid

• Status: Unknown status
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Clinical observation frequently shows a paradoxical effect of topical corticosteroids in charge of a sudden melting of edema in the first days of treatment, which could be due to mobilization of extracellular. No study has shown the value of this measure in patients treated with topical steroids. This uncertainty, coupled with the observation of the paradoxical effects of topical steroids on edema are some patients that despite the systemic absorption of clobetasol propionate, a salt-free diet is not currently recommended practice.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Rouen
• Collaborator: Société de Dermatologie Française
• Treatments: Clobetasol

Criteria

Inclusion Criteria:

• Patient with age higher than 18

• Patient with bullous pemphigoid,

• Patient treated by local corticosteroid therapy (clobetasol propionate cream) but not yet processed or for less than 48 hours,

• Signed informed consent.

• Patient affiliated to Social Security Regimen

• Effective contraception in women of childbearing age (for postmenopausal women, confirmatory diagnosis of menopause will be collected)

Exclusion Criteria:

• Concomitant treatment with corticosteroids

• Recent introduction or recent (<6 weeks) treatment with diuretics, angiotensin-converting enzyme, receptor antagonist or anti-angiotensin renin (aliskiren)

• contraindication to the use of Clobetasol propionate (DERMOVAL and CLARELUX)

• Patient on salt diet (- Patients carry a defibrillator or a pace maker

• Amputated Patient

• Pregnant and lactating

• Patient with Urinary Incontinency

• Recent heart decompensation in the last 6 weeks

• known Nephrotic Syndrome

• known or Severe hepatic impairment

• Hypoalbuminaemia less than 20 g / l