Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock
Status:
Unknown status
Trial end date:
2019-05-30
Target enrollment:
Participant gender:
Summary
Despite recent medical advances, sepsis and septic shock remain a major cause of death.
Sepsis is a syndrome with a wide array of physiologic, pathologic, and biochemical
abnormalities.
Several studies have shown vitamin C have decreased the circulating pro-inflammatory
cytokines and oxidative stress.Thiamine had favorable effects on pro-inflammatory cytokines,
oxidative stress and cellular hypoxia.The use of hydrocortisone in combination with vitamin C
will increase the transport of vitamin C into the cells; since the pro inflammatory cytokines
have shown to decrease the expression of the sodium-vitamin C transporter-2 (SVCT2) while
glucocorticoids increase the SVCT2 expression.
A recent small retrospective study , showed a significant decrease in mortality when patients
with severe sepsis and septic shock are treated with a combination of Hydrocortisone, Vitamin
C, and Thiamine. Conducting a similar study with a prospective randomized design will give
clinicians all over the world more answers and will help clinicians to provide better care to
millions of patients using highly safe therapeutic regimen.
The objective of the current study is to explore the clinical benefits of using a combination
of hydrocortisone, vitamin C, and thiamine (triple therapy) for the management of septic
shock. To achieve this objective, we will compare two alternative treatment strategies,
either triple therapy or usual care in patients with septic shock.
First aim: To assess the effectiveness of the triple therapy for septic shock
Second aim: To assess the safety of triple therapy