Evaluation of Inter-reader Reliability Using Images From Subjects With Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI)

• Status: Completed
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Re-read of brain amyloid scans acquired in previous AV-45 clinical studies by readers trained using updated reading methodology. The scans in this study came from subjects who had Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Avid Radiopharmaceuticals

Criteria

Participants:

• Inclusion Criteria AD:

• Male or female >=50 years of age

• Meet National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) criteria for probable AD with Mini-Mental State Examination (MMSE) score of 10-24

• Inclusion Criteria MCI:

• Male or female >=50 years of age

• Have a Clinical Dementia Rating (CDR) of 0.5

• MMSE >24

• Exclusion Criteria:

• Have a history or current diagnosis of other neurologic disease

• Have had or currently have a diagnosis of other neurodegenerative disease

• Have participated in experimental therapy targeted to amyloid plaque

Readers:

•Private nuclear medicine physicians with no prior training in reading florbetapir-PET scans