Evaluation of Intraarticular Tranexamic Acid to Reduction of Total Blood Loss Following Knee-Arthroplasty

• Status: Completed
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: All

Summary

A randomized, prospective, placebo-controlled study which aims to evaluate the effect of combined intraarticular and intravenous Tranexamic acid on total blood loss following unilateral knee replacement versus only intravenous tranexamic acid.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hvidovre University Hospital
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• > 18 years old

• Unilateral knee replacement

• Must be able to give oral and written consent

Exclusion Criteria:

• General Anesthetized

• Allergic to Tranexamic acid

• In treatment with the following anticoagulants: Adenosine diphosphate receptor inhibitors or vitamin K antagonist within in the last 5 days. Factor Xa inhibitor and thrombin inhibitor.

• Use of oral anticonceptive.

• Reduced kidney function (S-creatinine > 120 micromol/L)

• Medicine or alcohol abuse

• Females with menstruation within the last 12 mounts.

• Any kind of cancer disease

• Rheumatoid arthritis

• Have participated in a clinical trial within the last 30 days.