Evaluation of Intraoperative Dexmedetomidine Use in Patients Undergoing Surgical Aortic Valve Replacement

• Status: Recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Aim of this randomized prospective study is to investigate the immunomodulatory effects of dexmedetomidine on outcomes in patients with isolated aortic stenosis after surgical aortic valve replacement.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Dubrava
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• isolated aortic stenosis adult patients with written consent

Exclusion Criteria:

• BMI >30kg/m2

• 1st, 2nd and 3rd degree AV block

• bradycardia HR<50/min upon arrival to operating theatre

• neurological disorders (Parkinson's disease, Myasthenia gravis, multiple sclerosis, brain tumors in anamnesis)

• recent use of psychoactive drugs

• alcohol and illicit drug addiction

• diabetes type I with complications

• patients who develop hypotension after initiation of dexmedetomidine infusion requiring vasoconstriction therapy

• patients receiving corticosteroids in perioperative period

• patients with known allergy to dexmedetomidine