Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp

• Status: Recruiting
• Trial end date: 2024-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The goal of this study is to understand how exogenous kisspeptin affects metabolism by evaluating responses to an hyperglycemic clamp

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Massachusetts General Hospital

Criteria

Inclusion Criteria:

over the age of 17 normal pubertal development regular menstrual cycles stable weight for previous three months normal body mass index blood pressure systolic BP < 140 mm Hg, diastolic < 90 mm Hg normal hemoglobin hemoglobin A1C < 6.5% BUN, creatinine not elevated AST, ALT < 3x upper limit of normal negative serum pregnancy test

Exclusion Criteria:

active illicit drug use, history of a medication reaction requiring emergency medical care, difficulty with blood draws. history of hypertension, diabetes, heart disease, high cholesterol, cancer, or clotting disorders.

history of chronic disease that has required hospitalization recent use of prescription medications which interfere with metabolism or reproduction (recent = within 5 half-lives of the drug) unless it is birth control history of diabetes in a first degree relative hyperlipidemia by fasting lipid panel