Evaluation of L-PRF as an Antibiotic Slow-release Biological Device in the Treatment of Moderate Periodontitis

• Status: Completed
• Trial end date: 2023-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aimed to evaluate the efficacy of leukocyte platelet-rich fibrin (L-PRF) as a local sustained released device for antibiotics.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yasmeen Khaled
• Treatments: Metronidazole

Criteria

Inclusion Criteria:

• Patients suffering from stage II periodontitis with probing depth and exhibiting bleeding on probing.

• Patients showing good oral hygiene.

• No history of periodontal therapy (surgical and non-surgical) for the past 6 months.

Exclusion Criteria:

• Patients with known systemic and debilitating diseases.

• Patients who had any previous adverse reactions to the products (or similar products) used in this study.

• Patients who have any autoimmune diseases.

• Patients who have any known disease that interfere with periodontal procedure.

• Smokers.

• Pregnancy and lactating women.

• Use of antibiotics during the last 6 months.