Evaluation of Meclizine Orodispersible Tablet Pharmacokinetic in Human Volunteers
Status:
Recruiting
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
The main goal of this study is to develop a new oro-dissolvable/dispersible tablet that will
augment the dual rapid absorption of MCZ from the buccal cavity as well as prolonging that
from the GIT. A dual function tablet is expected to encompass an outer coat of the drug with
special excipients that will rapidly disperse and the drug get dissolve and absorb in the
buccal cavity and an inner core that will similarly, disperse to release MCZ coated
nanoparticles in the saliva. The latter will be subsequently swallowed without water to be
absorbed in a prolonged manner from the GIT. This will be advantageous for geriatric as well
as pediatric patients, besides, those suffering from dysphagia. The pharmacokinetics profile
of the prepared dual function tablet will be assessed in human volunteers through
noncompartmental analysis.