Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects

• Status: Enrolling by invitation
• Trial end date: 2024-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this clinical trial is to assess the effectiveness of local delivery of melatonin and metformin loaded nanoparticle gel as adjunct to scaling and root planning (SRP) in the treatment of periodontal intra bony defect.

fifty two healthy patients(n=52) with at least one periodontal intra-bony defect will be included in the study, all selected patients will be motivated about the benefit of plaque control and periodontal treatment . The participant will be selected from outpatient clinic of the Department of Oral Medicine and Periodontology , Faculty of dentistry, Mansoura University . The participant will be classified into four groups :group I and II are test groups but group III and IV are control groups .Patients in group I will be treated with melatonin loaded nanoparticle gel while in group II will be treated with melatonin and metformin loaded nanoparticles which will be applied weekly for four weeks after SRP had been completed and group III will be treated with placebo gel while group IV will be treated with only scaling and root planning.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Amira ragab
• Treatments: Melatonin; Metformin

Criteria

Inclusion Criteria:

• patients with at least one intra-bony defect diagnosed clinically and radiographically

Exclusion Criteria:

• Patients with systemic diseases.

• Pregnant and lactating females.

• Smokers and tobacco chewers.

• History of antibiotic and periodontal therapy in the last 3 months.

• Patients not compliant with oral hygiene procedures.

• Patients with a known or suspected allergy to the melatonin or metformin.

• Individuals on systemic drug affecting metabolic bone diseases and medically compromised patients.