Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial

• Status: Recruiting
• Trial end date: 2024-05-01

Summary

Opioid-free anesthesia (OFA) is a general anesthesia based on the use of hypnotics and non-opioid analgesics (lidocaine, ketamine, dexamethasone, esmolol). This technique has been used for the past 10 years, during which randomized and non-randomized studies have demonstrated a number of positive effects on cardiac function:

• better analgesia and decreased postoperative morphine consumption,

• better respiratory function,

• better hemodynamic stability,

• better postoperative cognitive function.

The hypothesis of the present study is that the use of OFA during cardiac surgery is associated with:

• Improved intraoperative hemodynamic stability

• A decrease in the incidence of postoperative complications

• A reduction in intensive care and hospital length of stay

• Phase: Phase 3

Details

• Lead Sponsor: Centre Hospitalier Universitaire Dijon
• Treatments: Anesthetics; Morphine