Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Iodine therapy is the best treatment for graves disease.Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy.

Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and others prefer longer off - methimazole period which bothers most patients. This study aimed to evaluate optimum time for methimazole discontinuation in graves disease.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mashhad University of Medical Sciences
• Treatments: Iodine; Methimazole

Criteria

Inclusion Criteria:

• age 18-65

• graves disease(TSH<0.1 &increased FT4 & positive TSI

• one or more bartlena criteria for radio-iodine therapy

• 24 hour RAIU>25%

• euthyroidism after methimazole treatment

Exclusion Criteria:

• pregnancy or lactation

• moderate or severe graves ophthalmopathy

• CHF or coronary heart disease

• palpable thyroid nodule

• lithium or amiodarone or lugol or ipodate treatment

• recent imaging with contrast agent

• very large goiter(more than 150 gram)