Evaluation of Oral ORIN1001 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
Status:
Recruiting
Trial end date:
2022-03-30
Target enrollment:
Participant gender:
Summary
This Phase 1b trial is a double-blind, placebo-controlled, multiple ascending dose study to
evaluate the safety and tolerability of oral ORIN1001 at 25 mg, 50 mg or 100 mg administered
daily for up to 28 days in adult subjects with idiopathic pulmonary fibrosis (IPF) alone or
in conjunction with local Standard of Care for IPF (pirfenidone or nintedanib).
A maximum of 24 evaluable subjects will be required to complete the study. The study will
consist of 3 dose cohorts each enrolling a maximum of 8 subjects randomized either to the
active (5 subjects) group or placebo (3 subjects) group. Each subject will receive daily oral
doses of ORIN1001 or placebo for 28 days.
The safety and pharmacokinetic profile will be evaluated in this study and will include
cardiovascular and pulmonary endpoints.