Evaluation of Periop Biochemical Stress Factors in Craniotomy Neurosurgical Procedure With Respect to Preop Hypertension
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
Perioperative hypertension is commonly associated with surgical craniotomy. As the
sympathetic nervous system and the renin-angiotensin-aldosterone system play a key role in
the development of this hypertension, preoperative single dose therapy with a -adrenergic
receptor blocker or an angiotensin converting enzyme (ACE) inhibitor may be useful in
preventing this. To assess this as well as to study potential markers of these two systems,
the investigators will perform a randomized, double blind, placebo controlled study to
compare the single dose effect of preoperative administration of a -receptor blocking drug
(atenolol) and an ACE inhibitor (lisinopril) with a control group receiving a placebo tablet
(glucose) on perioperative hypertension in craniotomy patients.