Evaluation of Pharmacokinetic and Pharmacodynamic Properties of Intravenous Colistimethate Sodium
Status:
Completed
Trial end date:
2019-06-01
Target enrollment:
Participant gender:
Summary
Colistin is a polymixin antibiotic used in the treatment of multidrug-resistant gram-negative
infections. Given the limited use of colistin and previous challenges with laboratory assays
to determine plasma concentrations, there is a lack of knowledge of the pharmacokinetic
profile of colistin. The purpose of the investigators observational prospective
pharmacokinetic cohort study is to examine the steady-state pharmacokinetic and
pharmacodynamic properties of intravenous colistimethate sodium in cystic fibrosis and
critically ill patients.