Evaluation of Remifentanil and Dexmedetomidine in Patients With Noninvasive Mechanical Ventilation Intolerance
Status:
Recruiting
Trial end date:
2023-02-28
Target enrollment:
Participant gender:
Summary
Currently, NIV(Noninvasive ventilation ) is widely used in patients with hypoxemia and
atelectasis after cardiac surgery.About 15% of patients have intolerance during NIV. The main
manifestation is that the patient feels uncomfortable, often breaks away from the mask, and
even gradually becomes agitated, which eventually leads to the failure of non-invasive
ventilation.The patient's intubation rate is as high as 44%, and the mortality rate is
34%.There are many ways to prevent or treat NIV intolerance, of which the most used is to
sedate the patient. This study aims to evaluate the effects of remifentanil and
dexmedetomidine in the sedation of patients with intolerance to non-invasive mechanical
ventilation after cardiac surgery, and to explore the optimal plan for sedation of patients
with intolerant non-invasive mechanical ventilation after cardiac surgery.